{
  "_id": "6ac786ccde46216d5edd19fb",
  "Package": "BBMBC",
  "Title": "Beta-Binomial Models for Vaccine-Specific Memory B Cell\nFrequency and Power Calculations",
  "Version": "0.1.0",
  "Authors@R": "person(\"Andrew\", \"Shin\", , \"ashin2@uw.edu\", role = c(\"aut\", \"cre\"))",
  "Description": "Provides tools to model overdispersed vaccine-specific\nmemory B cell frequencies using Beta-Binomial generalized\nlinear models, specifically designed for analyzing\nvaccine-induced cellular immune responses. Includes\nmethod-of-moments dispersion estimation, likelihood ratio\ntesting across experimental arms, and Monte Carlo simulation\nframeworks to calculate statistical power and Type I error\nrates. The methodologies are directly motivated by the analysis\nof immunology data in 'Vaccination with mRNA-encoded\nmembrane-anchored HIV envelope trimers elicited tier 2\nneutralizing antibodies in a phase 1 clinical trial' (Parks et\nal. 2025) <doi:10.1126/scitranslmed.ady6831>.",
  "Encoding": "UTF-8",
  "Config/testthat/edition": "3",
  "Config/roxygen2/version": "8.0.0",
  "License": "MIT + file LICENSE",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-10-08 11:45:25 UTC",
    "User": "root"
  },
  "Author": "Andrew Shin [aut, cre]",
  "Maintainer": "Andrew Shin <ashin2@uw.edu>",
  "Config/pak/sysreqs": "cmake make libicu-dev",
  "Repository": "https://ashin2117.r-universe.dev",
  "Date/Publication": "2026-10-07 08:10:20 UTC",
  "RemoteUrl": "https://github.com/cran/BBMBC",
  "RemoteRef": "HEAD",
  "RemoteSha": "b04233200919bc185c76b89d3af9d4f0876a1004",
  "_user": "ashin2117",
  "_type": "src",
  "_file": "BBMBC_0.1.0.tar.gz",
  "_fileid": "https://r2.ropensci.org/58c1ede2747b371b116d2bc213d579d323420a727d17647b92dcac0cb1f5fcc0",
  "_filesize": 101086,
  "_sha256": "58c1ede2747b371b116d2bc213d579d323420a727d17647b92dcac0cb1f5fcc0",
  "_expires": "2027-01-16T12:04:26.000Z",
  "_created": "2026-10-08T11:45:25.000Z",
  "_published": "2026-10-08T12:04:28.693Z",
  "_buildurl": "https://github.com/r-universe/ashin2117/actions/runs/37771823271",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_jobs": [
    {
      "job": 113294266992,
      "time": 155,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "11547468621"
    },
    {
      "job": 113294267091,
      "time": 158,
      "config": "linux-release-x86_64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "11548592751"
    },
    {
      "job": 113294267042,
      "time": 203,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "11549920175"
    },
    {
      "job": 113294267071,
      "time": 257,
      "config": "macos-release-arm64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "11549925270"
    },
    {
      "job": 113293098988,
      "time": 185,
      "config": "source",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "11548048097"
    },
    {
      "job": 113294267194,
      "time": 119,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "11547818164"
    },
    {
      "job": 113294267306,
      "time": 109,
      "config": "windows-devel-x86_64",
      "r": "4.7.0",
      "check": "OK",
      "artifact": "11548228216"
    },
    {
      "job": 113294267156,
      "time": 105,
      "config": "windows-oldrel-x86_64",
      "r": "4.5.3",
      "check": "OK",
      "artifact": "11548247724"
    },
    {
      "job": 113294267092,
      "time": 114,
      "config": "windows-release-x86_64",
      "r": "4.6.1",
      "check": "OK",
      "artifact": "11547453614"
    }
  ],
  "_upstream": "https://github.com/cran/BBMBC",
  "_commit": {
    "id": "b04233200919bc185c76b89d3af9d4f0876a1004",
    "author": "Andrew Shin <ashin2@uw.edu>",
    "committer": "cran-robot <csardi.gabor+cran@gmail.com>",
    "message": "version 0.1.0\n",
    "time": 1791360620
  },
  "_maintainer": {
    "name": "Andrew Shin",
    "email": "ashin2@uw.edu",
    "login": "ashin2117",
    "description": "Undergraduate Student, Mathematics University of Washington, Seattle",
    "uuid": 173746241
  },
  "_distro": "resolute",
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 4.1.0",
      "role": "Depends"
    },
    {
      "package": "doParallel",
      "role": "Imports"
    },
    {
      "package": "foreach",
      "role": "Imports"
    },
    {
      "package": "glmmTMB",
      "role": "Imports"
    },
    {
      "package": "parallel",
      "role": "Imports"
    },
    {
      "package": "stats",
      "role": "Imports"
    },
    {
      "package": "utils",
      "role": "Imports"
    },
    {
      "package": "testthat",
      "version": ">= 3.0.0",
      "role": "Suggests"
    }
  ],
  "_owner": "cran",
  "_selfowned": true,
  "_usedby": 0,
  "_updates": [
    {
      "week": "2026-41",
      "n": 1
    }
  ],
  "_tags": [
    {
      "name": "0.1.0",
      "date": "2026-10-07"
    }
  ],
  "_stars": 0,
  "_contributors": [
    {
      "user": "ashin2117",
      "count": 1,
      "uuid": 173746241
    }
  ],
  "_userbio": {
    "uuid": 173746241,
    "type": "user",
    "name": "Andrew (Andy) Shin",
    "followers": 0,
    "description": "Undergraduate Student, Mathematics University of Washington, Seattle"
  },
  "_downloads": {
    "count": 0,
    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/BBMBC"
  },
  "_searchresults": 0,
  "_rbuild": "4.6.1",
  "_assets": [
    "extra/BBMBC.html",
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/manual.pdf",
    "LICENSE"
  ],
  "_realowner": "ashin2117",
  "_cranurl": false,
  "_releases": [
    {
      "version": "0.1.0",
      "date": "2026-10-07"
    }
  ],
  "_exports": [
    "calc_power_bb",
    "calc_rho_mom",
    "calc_t1_bb",
    "test_diff_bb"
  ],
  "_help": [
    {
      "page": "calc_power_bb",
      "title": "Calculate Statistical Power for Beta-Binomial Models (Parallelized)",
      "topics": [
        "calc_power_bb"
      ]
    },
    {
      "page": "calc_rho_mom",
      "title": "Estimate Overdispersion (Rho) via Method of Moments",
      "topics": [
        "calc_rho_mom"
      ]
    },
    {
      "page": "calc_t1_bb",
      "title": "Calculate Type I Error for Beta-Binomial Models",
      "topics": [
        "calc_t1_bb"
      ]
    },
    {
      "page": "test_diff_bb",
      "title": "Beta-Binomial Likelihood Ratio Test for Group Differences",
      "topics": [
        "test_diff_bb"
      ]
    }
  ],
  "_rundeps": [
    "backports",
    "boot",
    "broom",
    "cli",
    "codetools",
    "colorspace",
    "cowplot",
    "cpp11",
    "Deriv",
    "doBy",
    "doParallel",
    "dplyr",
    "farver",
    "foreach",
    "forecast",
    "fracdiff",
    "generics",
    "ggplot2",
    "glmmTMB",
    "glue",
    "gtable",
    "isoband",
    "iterators",
    "labeling",
    "lattice",
    "lifecycle",
    "lme4",
    "lmtest",
    "magrittr",
    "MASS",
    "Matrix",
    "mgcv",
    "minqa",
    "modelr",
    "nlme",
    "nloptr",
    "nnet",
    "numDeriv",
    "pbkrtest",
    "pillar",
    "pkgconfig",
    "purrr",
    "R6",
    "rbibutils",
    "RColorBrewer",
    "Rcpp",
    "RcppArmadillo",
    "RcppEigen",
    "Rdpack",
    "reformulas",
    "rlang",
    "RTMB",
    "S7",
    "sandwich",
    "scales",
    "stringi",
    "stringr",
    "tibble",
    "tidyr",
    "tidyselect",
    "timeDate",
    "TMB",
    "urca",
    "utf8",
    "vctrs",
    "viridisLite",
    "withr",
    "zoo"
  ],
  "_score": 1,
  "_indexed": true,
  "_nocasepkg": "bbmbc",
  "_universes": [
    "ashin2117"
  ],
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "0.1.0",
      "date": "2026-10-08T11:47:34.000Z",
      "distro": "resolute",
      "commit": "b04233200919bc185c76b89d3af9d4f0876a1004",
      "fileid": "https://r2.ropensci.org/4afad0c10efc075a5eb00209408a2e66ad80672d0ec0ffc692ae03d9e491a069",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/ashin2117/actions/runs/37771823271"
    },
    {
      "r": "4.6.1",
      "os": "linux",
      "version": "0.1.0",
      "date": "2026-10-08T11:47:39.000Z",
      "distro": "resolute",
      "commit": "b04233200919bc185c76b89d3af9d4f0876a1004",
      "fileid": "https://r2.ropensci.org/420892919f57ff3eecaa655e094b3b5188952ba94f900b0d51d02bf7ea6a78ff",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/ashin2117/actions/runs/37771823271"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "0.1.0",
      "date": "2026-10-08T12:02:02.000Z",
      "commit": "b04233200919bc185c76b89d3af9d4f0876a1004",
      "fileid": "https://r2.ropensci.org/50d512b2704bafa3fdbdb25f7a4183ae59772b728f23b9356c24672980dbe07e",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/ashin2117/actions/runs/37771823271"
    },
    {
      "r": "4.6.1",
      "os": "mac",
      "version": "0.1.0",
      "date": "2026-10-08T12:02:07.000Z",
      "commit": "b04233200919bc185c76b89d3af9d4f0876a1004",
      "fileid": "https://r2.ropensci.org/da0474cca24d05d6368652ae1737147f241aa74232cd456f113b3b366d6ec47d",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/ashin2117/actions/runs/37771823271"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "0.1.0",
      "date": "2026-10-08T11:47:44.000Z",
      "commit": "b04233200919bc185c76b89d3af9d4f0876a1004",
      "fileid": "https://r2.ropensci.org/bb68ed3abf7742e9c4683984333d9d5f21760b1e4bc3f6da64e030ef1e5ccc21",
      "status": "success",
      "buildurl": "https://github.com/r-universe/ashin2117/actions/runs/37771823271"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "0.1.0",
      "date": "2026-10-08T11:46:41.000Z",
      "commit": "b04233200919bc185c76b89d3af9d4f0876a1004",
      "fileid": "https://r2.ropensci.org/64c44a4f800200d3222501ae2bb2da10cadd34c2610be30bfaccd29cdcc9d036",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/ashin2117/actions/runs/37771823271"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "0.1.0",
      "date": "2026-10-08T11:46:45.000Z",
      "commit": "b04233200919bc185c76b89d3af9d4f0876a1004",
      "fileid": "https://r2.ropensci.org/20a3eaca92ea4f6c8dfb5ac35b4b1143fe3fc27c1534921b8e1e8fd9fe3999bc",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/ashin2117/actions/runs/37771823271"
    },
    {
      "r": "4.6.1",
      "os": "win",
      "version": "0.1.0",
      "date": "2026-10-08T11:46:48.000Z",
      "commit": "b04233200919bc185c76b89d3af9d4f0876a1004",
      "fileid": "https://r2.ropensci.org/7a0ce7d65fa53182046e6c85421589ca44932147b4e61724f42fa111811d8106",
      "status": "success",
      "check": "OK",
      "buildurl": "https://github.com/r-universe/ashin2117/actions/runs/37771823271"
    }
  ]
}