Package: BBMBC 0.1.0
BBMBC: Beta-Binomial Models for Vaccine-Specific Memory B Cell Frequency and Power Calculations
Provides tools to model overdispersed vaccine-specific memory B cell frequencies using Beta-Binomial generalized linear models, specifically designed for analyzing vaccine-induced cellular immune responses. Includes method-of-moments dispersion estimation, likelihood ratio testing across experimental arms, and Monte Carlo simulation frameworks to calculate statistical power and Type I error rates. The methodologies are directly motivated by the analysis of immunology data in 'Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial' (Parks et al. 2025) <doi:10.1126/scitranslmed.ady6831>.
Authors:
BBMBC_0.1.0.tar.gz
BBMBC_0.1.0.zip(r-4.7-any)BBMBC_0.1.0.zip(r-4.6-any)BBMBC_0.1.0.zip(r-4.5-any)
BBMBC_0.1.0.tgz(r-4.6-any)BBMBC_0.1.0.tgz(r-4.5-any)
BBMBC_0.1.0.tar.gz(r-4.7-any)BBMBC_0.1.0.tar.gz(r-4.6-any)
BBMBC_0.1.0.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION
card.svg |card.png
BBMBC/json (API)
| # Install 'BBMBC' in R: |
| install.packages('BBMBC', repos = c('https://ashin2117.r-universe.dev', 'https://cloud.r-project.org')) |
This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.
Last updated from:b042332009. Checks:9 OK. Indexed: yes.
| Target | Result | Time | Files | Syslog |
|---|---|---|---|---|
| linux-devel | OK | 155 | ||
| source / vignettes | OK | 185 | ||
| linux-release | OK | 158 | ||
| macos-release | OK | 257 | ||
| macos-oldrel | OK | 203 | ||
| windows-devel | OK | 109 | ||
| windows-release | OK | 114 | ||
| windows-oldrel | OK | 105 | ||
| wasm-release | OK | 119 |
Exports:calc_power_bbcalc_rho_momcalc_t1_bbtest_diff_bb
Dependencies:backportsbootbroomclicodetoolscolorspacecowplotcpp11DerivdoBydoParalleldplyrfarverforeachforecastfracdiffgenericsggplot2glmmTMBgluegtableisobanditeratorslabelinglatticelifecyclelme4lmtestmagrittrMASSMatrixmgcvminqamodelrnlmenloptrnnetnumDerivpbkrtestpillarpkgconfigpurrrR6rbibutilsRColorBrewerRcppRcppArmadilloRcppEigenRdpackreformulasrlangRTMBS7sandwichscalesstringistringrtibbletidyrtidyselecttimeDateTMBurcautf8vctrsviridisLitewithrzoo
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Calculate Statistical Power for Beta-Binomial Models (Parallelized) | calc_power_bb |
| Estimate Overdispersion (Rho) via Method of Moments | calc_rho_mom |
| Calculate Type I Error for Beta-Binomial Models | calc_t1_bb |
| Beta-Binomial Likelihood Ratio Test for Group Differences | test_diff_bb |