BBMBC - Beta-Binomial Models for Vaccine-Specific Memory B Cell Frequency and Power Calculations

Provides tools to model overdispersed vaccine-specific memory B cell frequencies using Beta-Binomial generalized linear models, specifically designed for analyzing vaccine-induced cellular immune responses. Includes method-of-moments dispersion estimation, likelihood ratio testing across experimental arms, and Monte Carlo simulation frameworks to calculate statistical power and Type I error rates. The methodologies are directly motivated by the analysis of immunology data in 'Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial' (Parks et al. 2025) <doi:10.1126/scitranslmed.ady6831>.